In Chapter 9, we delve into the critical intersection of pharmaceutical regulations and digital technology, focusing on drug information management and internet-based drug information services. This chapter explores the legal framework, best practices, and challenges in ensuring that accurate, timely, and safe drug information is disseminated online. Key topics include the classification of drug information, regulatory requirements for online platforms (such as licensing and content verification), privacy protection for user data, and the role of surveillance in preventing misinformation and illegal sales. By analyzing case studies and current models, we underscore the importance of integrating robust quality control mechanisms and patient-centric approaches to enhance public health outcomes in the digital era.